Low and High Radio-Iodine-131 Doses in Postoperative Ablation in Differentiated Thyroid Carcinoma

The goals of post-surgical RAI therapy in patients with differentiated DTC are to ablate residual normal thyroid tissue that may facilitate surveillance,) Also the potential tumoricidal effect on residual microscopic RAI-avid disease, and to provide a posttreatment whole-body scan that may reveal undetected local or distant metastases.Although, these goals are important, the ultimate endpoint of postsurgical ablation is to minimize DTC recurrence and death by eliminating residual normal thyroid tissue or residual microscopic disease that could be a focus for future recurrence(1).